Publications

[64] Yongjun Mao, Ruisheng Xiong, Zheng Liu, Haihong Li, Jingkang Shen, Jingshan Shen. Novel and practical synthesis of candesartan cilexetil. Heterocycles. 2010, 81(6), 1503-1508

[63] Zhi Chen, Guanghui Tian, Zhen Wang, Hualiang Jiang, Jingshan Shen, Weiliang Zhu. Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity. Journal of Chemical Information and Modeling.2010, 50(4), 615-625

[62] Jianfeng Li, Zhen Wang, Guanghui Tian, Zheng Liu, Jingshan Shen. TPN729, a Potent and Selective PDE5 Inhibitor for ED and PAH Treatment. The 7th International symposium for Chinese Medicinal Chemists.Kaohsiung, 2010, 182

[61] Qiang Zhang, Qingjie Zhao, Ruisheng Xiong, Jianfeng Li, Jingshan Shen. Research progress in anti-influenza virus agents. Acta Pharmaceutica Sinica. 2010, 45(3), 289-299 (Chinese)

[60] Yongjun Mao, Guanghui Tian, Zheng Liu, Jingkang Shen, Jingshan Shen. An Improved Synthetic Route for Preparative Process of Vardenafil. Organic Process Research & Development. 2009, 13 (6), 1206-1208

[59] Yuanyuan Lou, Jianfeng Li, Yabing Wei. Total synthesis of (±)-stepholidine. Chinese Journal of Medicinal Chemistry. 2009, 19 (5), 361-363. (Chinese)

[58] Qifeng Zhu, Haihong Li, Guangming Liu. A novel synthesis of antihypertensive drug candesartan cilexitil. Chinese Journal of Medicinal Chemistry. 2009, 19 (3), 185-187. (Chinese)

[57] Xiangrui Jiang; Jianfeng Li; Rongxia Zhang; Hongli Guo; Shaolei Huang, Jingshan Shen. Improved Preparation of 3-(1,1-Dimethylallyl)decursinol. Journal of Heterocyclic Chemistry. 2009, 46, 560-562

[56] Hongliang Duan, Jin Zheng, Qinglin Lai, Zheng Liu, Guanghui Tian, Zhen Wang, Jianfeng Li, Jingshan Shen. 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6. Bioorganic & Medicinal Chemistry Letters. 2009(10), 19, 2777-2779

[55] Xiaohui Wei, Xuemei Cheng, Jingshan Shen, Zhengtao Wang. Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair. Journal of Ethnopharmacology. 2008,117 (2), 339-344.

[54] Jin Zheng, Zheng Liu, Yiru Dai, Qingjie Zhao, Jingshan Shen. Synthesis of Related Substances of Cilostazol. Heterocycles. 2009, 78 (1), 189-195.

[53] Peixuan Zhang, Jianfeng Li, Yabing Wei, Jingshan Shen. NMR characterization and structural elucidation of fluorine derivative of tetrahydroberberine. Chinese Journal of Magnetic Resonance. 2009, 26 (1), 111-119. (Chinese)

[52] Peixuan Zhang, Yongjun Mao, Jingshan Shen, Yabing Wei. Synthesis of an antitumor agent neratinib. Chinese Journal of Medicinal Chemistry. 2008,18 (5), 355-357. (Chinese)

[51] Jin Zheng, Qinglin Lai, Yiru Dai, Qingjie Zhao, Jingshan Shen. Synthesis of substances related to fluticasone propionate.Organic Preparations and Procedures International. 2008, 40 (6), 566- 571.

[50] Xiangrui Jiang, Jianfeng Li, Rongxia Zhang, Yi Zhu, Jingshan Shen. An Improved Preparation Process for Gemcitabine. Organic Process Research & Development. 2008, 12 (5), 888-891.

[49] Zheng Liu, Haihong Li, Qingjie Zhao, Jingshan Shen. A Facile One-pot Synthesis of Benzimidazoles from 2-Nitroanilines by Reductive Cyclization. Heterocycles. 2008, 75 (8), 1907-1911.

[48] Qingjie Zhao, Haihong Li, Fuqiang Zhu, Hongli Guo, Jingshan Shen. A Practical Synthesis of 4-Acetyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine. Organic Preparations and Procedures International. 2008, 40 (5), 490-493.

[47] Qingjie Zhao, Yuanyuan Lou, Ruisheng Xiong, Haihong Li, Jingshan Shen. Regioselective Synthesis of 4azido-Neu2en5,7Ac21Me and its intramolecular Transformation to 4azido-Neu2en5,9Ac21Me. Carbohydrate Research. 2008, 343, (14), 2459-2462.

[46] Qingjie Zhao, Zheng Liu, Jin Zheng, Jingshan Shen. 4-Acetyl-2,3,4,5- tetrahydrobenzodiazepine. Acta Crystallographica Section E-Structure Reports Online. 2008, 64, o969.

[45] Bin Li, Jianfeng Li, Lei Fu, Xiaoguang Sun, Jianjun Liu, Gang Huang. Synthesis and evaluation of a trace for peripheral benzodiazepine receptors. Chemical Journal of Chinese Universities. 2008, 29 (1), 86-89. (Chinese)

[44] Yongjun Mao, Peixuan Zhang, Guanghui Tian, Zhen Wang, Jingshan Shen. Advances in the inhibitors of vascular endothelial growth factor receptor tyrosine kinase. Chinese Journal of New Drugs. 2008,17 (7), 10-15. (Chinese)

[43] Yongjun Mao, Haihong Li, Jianfeng Li, Jingshan Shen. Signal transduction by protein tyrosine kinases and antitumor agents. Acta Pharmaceutica Sinica. 2008, 43 (4), 323-334. (Chinese)

[42] Chi Yang, Jianfeng Li, Haihong Li, Yabing Wei. Graphical synthetic routes of candesartan celexicitil. Chinese Journal of Pharmaceuticals. 2008, 39 (3), 222-224. (Chinese)

[41] Guanghui Tian, Guangxin Xia, Weixi Jin, Xinjian Chen, Shunan Lai, Yabing Wei, Ruyun Ji, Jingshan Shen. Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2’,1’:5,1] pyrazolo[4,3-d]pyrimidin-4- one Derivatives. Chinese Journal of Chemistry. 2007, 25, 241-245.

[40] Jianfeng Li, Aixiang Liu, Guangxin Xia, Yifeng Nian, Jingshan Shen. Spectroscopic studies of aripiprazole. Spectroscopy and Spectral Analysis. 2007, 27 (5), 863-867. (Chinese)

[39] Bo Zhao, Yuzhi Rong, Xiaohua Huang, Jingshan Shen. Experimental and theoretical study on the structure and electronic spectra of imiquimod and its synthetic intermediates.Bioorganic & Medicinal Chemistry Letters. 2007, 17, 4942-4946.

[38] Jiao Mo, Yang Guo, Yushe Yang, Jingshan Shen, Guozhang Jin, Xuechu Zhen. Recent Developments in Studies of l-Stepholidine and its Analogs: Chemistry, Pharmacology and Clinical Implications. Current Medicinal Chemistry. 2007, 14 (28), 2996-3002

[37] Qinglin Lai, Qingjie Zhao, Zheng Liu, Jingshan Shen. 3,5-Dimethoxyacetanilide. Acta Crystallographica Section E-Structure Reports Online. 2007, 63, 2782

[36] Qingjie Zhao, Zheng Liu, Qinglin Lai, Jingshan Shen, Jingkang Shen. Scalable Synthesis of Influenza Virus Neuraminidase Inhibitor Zanamivir. The 5th National Conference on Organic Chemistry. Zhengzhou, 2007, 467

[35] Weixi Jin, Qingjie Zhao, Qinglin Lai, Yabing Wei. Synthesis of zanamivir. Chinese Journal of Pharmaceuticals. 2007,38(5),321-324. (Chinese)

[34] Li Shen, Xinliang Wang. Discuss on the Antidepressant Research of Chinese Traditional Medicine. Chinese Journal of Information on Traditional Chinese Medicine. 2007, 14(10),81-82. (Chinese)

[33] Li Shen, Xinliang Wang, Zhen Wang, Jingshan Shen. Progress in Research of Traditional Chinese Medicine and Natural Products in Antiobesity Field. Chinese Journal of Pharmacentical Technolgy Economics & Management. 2007,1(6),23-29. (Chinese)

[32] Jianfeng Li, Guozhang Jin, Jingshan Shen, Ruyun Ji. l-Chloroscoulerine Mesylate. Drugs of the Future.2006, 31 (5), 379-384.

[31] Jianfeng Li, Zheng Liu, Aixiang Liu, Jingkang Shen, Guozhang Jin, Ruyun Ji, Jingshan Shen. Synthesis and Pharmacological Profile of Tetrahydroproto- berberine Derivatives as Novel Dopamine Receptor Ligands. The 5th International symposium for Chinese Medicinal Chemists.Nanjing, 2006, 176-177.

[30] Xiaohui Wei, Yue Chen, Guangxin Xia, Jingshan Shen, Ruyun Ji. Studies of Chemical constituents of Ginkgo biloba and inhibitory activities on PDE5. Chinese Traditional and Herbal Drugs. 2006, 37 (7), 993-995. (Chinese)

[29] Yue Chen, Jianfeng Li, Yabing Wei, Jingshan Shen. Spectral data deduced structure of new drug lomerizine dihydrochloride. Chinese Journal of Magnetic Resonance. 2006, 23 (3), 341-348. (Chinese)

[28] Xiaohui Wei, Shujun Zhang, Guangxin Xia, Shou Fu, Wei Wang, Jingshan Shen, Ruyun Ji. Inhibitation of coumarins in cnidium monnieri cusson and angelian dahuricn on PDE5. Chinese Pharmaceutical Journal. 2006, 41 (2), 100-101. (Chinese)

[27] Xiaohui Wei, Yue Chen, Guangxin Xia, Jingshan Shen. Antidepressant effect of “Yueju Pills” ethanol extract and water extract in mice models of depression. Shanghai Journal of Traditional Chinese Medicine. 2006, 40 (8), 70-71. (Chinese)

[26] Liang Fang, Xiaohui Wei, Qiaojun He, Peihua Luo, Lingling Fan, Bo Yang, Jingshan Shen. Studies on treatment of menopausal syndrome with angeng capsules. Chinese Pharmaceutical Journal. 2006, 41 (22), 1741-1744. (Chinese)

[25] Bin Li, Jianfeng Li, Xuebin Wang, Gang Huang. Synthesis and iodine-radiolabelling of peripheral benzodiazepine receptor tracer 131I-CLINDE. Nuclear Techniques. 2006, 29 (10), 777-781. (Chinese)

[24] Hongli Guo, Minjie Wang, Jin Zheng, Shujun Zhang, Jingshan Shen. Studies on chemical constituents of epimedium brevicormum.Chinese Pharmaceutical Journal. 2006, 41 (14), 1060-1062. (Chinese)

[23] Guangxin Xia, Jianfeng Li, Aiming Peng, Shunan Lai, Shujun Zhang, Jingshan Shen, Zhonghua Liu, Xinjian Chen, and Ruyun Ji. Synthesis and Phosphodiesterase 5 Inhibitory Activity of Novel Pyrido[1,2-e] purin-4(3H)-one Derivatives. Bioorganic & Medicinal Chemistry Letters. 2005, 15 (11), 2790-2794.

[22] Guangxin Xia, Jianfeng Li, Shunan Lai, Aiming Peng, Shujun Zhang, Xiaohui Wei, Xinjian Chen, Jingshan Shen, Ruyun Ji. Design and Synthesis of Pyrido[1,2-e]purin-4(3H)-one Derivatives as Potential PDE 5 Inhibitors.Chinese Chemical Letters. 2005,16 (10), 1283-1286

[21] Bin Li, Jianfeng Li, Gang Huang. A novel process for synthesis fo imidazo-[1,2-a] pyridine ligand as the peripheral benzodiazepine receptors. Academic Journal of ShanghaiSecondMedicalUniversity. 2005, 25 (12), 1242-1245. (Chinese)

[20] Shujun Zhang, Jingshan Shen, Jinlan Wang, Ruyun Ji, Masayoshi Ando. Synthesis of taxoids against multidrug resistant tumor cells. Chinese Journal of New Drugs. 2005, 14 (5), 579-581. (Chinese)

[19] Guangxin Xia, Jingshan Shen, Ruyun Ji. Advances on treatment of male erectile dysfunction. Advance in Pharmaceutical Sciences. Vol 2002, 98-126. Beijing,China Medicinal Science & Technology Press, 2003. (Chinese)

[18] Lijun Lei, Jianfeng Li, Qiaofang Ma, Jingshan Shen, Ruyun Ji. Spectral data analysis and identification of desloratidine. Chinese Journal of Analytical Chemistry. 2003, 31 (3), 257-260. (Chinese)

[17] Guangxin Xia, Rongxia Zhang, Jin Suo, Yi Zhu, Jingshan Shen, Ruyun Ji. Spectral data analysis and identification of imiquimod. Chinese Journal of Analytical Chemistry. 2003, 31 (10), 1183-1186. (Chinese)

[16] Jingshan Shen, Lijun Lei, Jianfeng Li, Ruyun Ji. Synthesis of hexahydro-1H-1,4- diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide) ethane and their analgesic effects. Chemical Journal of Chinese Universities.2002, 23 (4), 585-590. (Chinese)

[15] Jingshan Shen, Jianfeng Li, Fei Li, Min Wei, Ruyun Ji. Synthesis of zaleplon. Chinese Journal of Pharmaceuticals. 2002, 33 (7), 313-4. (Chinese)

[14] Lijun Lei, Rongxia Zhang, Songbai Liu, Jie Yang, Jing Zha, Jingshan Shen, Ruyun Ji. NMR assignment of candesartan cilexetil, a nonpeptide angiotensin II receptor antagonist. Chinese Journal of Magnetic Resonance. 2002, 19 (3), 269-273. (Chinese)

[13] Jingshan Shen, Lijun Lei, Haifang Mao, Jianfeng Li, Ruyun Ji. Synthesis of 5-Substituted Hexahydro-1H-1,4-Diazepine Analogues. Chinese Chemical Letters. 2001, 12 (11), 951-954.

[12] Jingshan Shen, Lijun Lei, Wei Lv, Jianfeng Li, Huijun Li, Ruyun Ji. Synthesis of hexahydro-1H-1,4-diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide)ethane (I). Chinese Journal of Synthetic Chemistry. 2001, 9 (3), 236-240. (Chinese)

[11] Jingshan Shen, Lijun Lei, Tiema Yan, Min Wei, Ruyun Ji. Synthesis of hexahydro-1H- 1,4-diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide) ethane (II). Acta Chimica Sinica. 2001, 59 (8), 1317-1322. (Chinese)

[10] Jingshan Shen, Lijun Lei, Tiema Yan, Jianfeng Li, Huijun Li, Zhenhua Li, Ruyun Ji. Synthesis of 2-Substitued hexahydro-1H-1,4-diazepine Analogues. Chinese Chemical Letters. 2001,12 (3),193-194.

[9] Jingshan Shen, Jianfeng Li, Haifang Mao, Ruyun Ji. Synthesis of sibutramine hydrochloride. Chinese Journal of Pharmaceuticals. 2001, 32(8), 337-339. (Chinese)

[8] Jingshan Shen, Bin Wang, Jianfeng Li, Lijun Lei, Ruyun Ji. Synthesis of leflunomide. Chinese Journal of Pharmaceuticals. 2001, 32 (2), 49-51. (Chinese)

[7] Jingshan Shen, Jianfeng Li, Huijun Li, Tiema Yan, Lijun Lei, Ruyun Ji, Guili Wang, Zhi Yang. Synthesis of imiquimod. Chemical Research and Application. 2001, 13 (3), 249-252. (Chinese)

[6] Jingshan Shen, Tiema Yan, Huijun Li, Jianfeng Li, Lijun Lei, Ruyun Ji. An improvement on the synthetic technology of irbesartan. Chinese Journal of Medicinal Chemistry. 2001, 11(2), 104-106. (Chinese)

[5] Jingshan Shen, Jianfeng Li, Huijun Li, Tiema Yan, Ruyun Ji. Facile synthesis of seratrodast. Chinese Journal of Medicinal Chemistry. 2001, 11 (4), 226-228. (Chinese)

[4] Lijun Lei, Jingshan Shen, Zhiyun Guo, Ruyun Ji. Study on mass spectrum of candesartan cilexetil, a novel nonpeptied angiotensin II receptor antagonist. Journal of Chinese Mass Spectrometry Society. 2001, 22 (4),11-15. (Chinese)

[3] Wei Lu, Guangrong Zheng, Jingshan Shen, Junchao Cai. Synthesis of the (3R,9S,10S)-diastereoisomer of panaxytriol, a potent antitumor polyacetylene from panax ginseng. Chinese Chemical Letters.1999, 10 (3), 201-204.

[2] Dongxiang Liu, Hualiang Jiang, Jingshan Shen, Weiliang Zhu, Lei Zhao, Kaixian Chen, Ruyun Ji. Molecular modeling on kappa opioid receptor and its interaction with nonpeptide kappa opioid agonists. Acta Pharmacologica Sinica. 1999, 20 (2), 131-136.

[1] Jingshan Shen, Dongxiang Liu, Hualiang Jiang, Ruyun Ji. The progress of selective non-peptide kappa opioid receptor agonists. Progress in Pharmaceutical Sciences. 1998, 22 (4), 193-199. (Chinese)

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